Elimusertib
Cat. No.：YN290669
CAS No. ：1876467-74-1
| 产品名称: | Elimusertib |
| CAS No.: | 1876467-74-1 |
| Chemical Name: | 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine |
| Synonyms: | BAY 1895344 |
| 分子量: | 375.42732 |
| 分子式: | C20H21N7O |
| SMILES: | CN1C(C2=CC(N3[C@@H](COCC3)C)=NC4=C2C=CN=C4C5=NNC=C5)=CC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elimusertib (BAY-1895344) 是一种有效、可口服、选择性的ATR抑制剂，IC50值为 7 nM，具有抗肿瘤活性。Elimusertib 可用于实体瘤和淋巴瘤的研究。 |
| IC50和靶点: | [{name:"ATR:7 nM (IC50)"}] |
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| Solvent & Solubility: |
Lücking, U., Wortmann, L., Wengner , A.M., et al.Damage incorporated: Discovery of the potent, highly selective, orally available ATR inhibitor BAY 1895344 with favorable pharmacokinetic properties and promising efficacy in monotherapy and in combination treatments in preclinical tumor modelsJ. Med. Chem.63(13),7293-7325(2020)
Wengner, A.M., Siemeister, G., Lücking, U., et al.The novel ATR inhibitor BAY 1895344 Is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer modelsMol. Cancer Ther.19(1),26-38(2020)
