NI-42
Cat. No.：YN310451
| 产品名称: | NI-42 |
| CAS No.: | 1884640-99-6 |
| Chemical Name: | 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-benzenesulfonamide |
| Synonyms: | compound 13-d |
| 分子量: | 353.39612 |
| 分子式: | C18H15N3O3S |
| SMILES: | O=S(C1=CC=C(C#N)C=C1)(NC2=CC(C=C(C)C(N3C)=O)=C3C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NI-42 (compound 13-d)，一种 BRPFS 正交结构的化学探针，是有偏向性的BRPFs 的溴结构域 (BRD)抑制剂 (IC50: BRPF1/2/3=7.9/48/260 nM;Kd: BRPF1/2/3=40/210/940 nM), 与非分类 IVBRD蛋白相比具有很好的选择性。 |
| IC50和靶点: | [{name:"BRPF1:7.9 nM (IC50)"},{name: "BRPF2:48 nM (IC50)"},{name: "BRPF3:260 nM (IC50)"},{name: "BRD9:310 nM (IC50)"},{name: "BRD4 (BD1):4500 nM (IC50)"},{name: "BRPF1:40 nM (Kd)"},{name: "BRPF2:210 nM (Kd)"},{name: "BRPF3:940 nM (Kd)"},{name: "BRD9:1130 nM (Kd)"},{name: "BRD7:82 nM (IC50)"}] |
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| Solvent & Solubility: |
Igoe, N., Bayle, E.D., Fedorov, O., et al.Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studiesJ. Med. Chem.60(2),668-680(2017)
Igoe, N., Bayle, E.D., Tallant, C., et al.Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteinsJ. Med. Chem.60(16),6998-7011(2017)
