SGC-SMARCA-BRDVIII
Cat. No.：YN310455
CAS No. ：1997319-84-2
| 产品名称: | SGC-SMARCA-BRDVIII |
| CAS No.: | 1997319-84-2 |
| Chemical Name: | 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester |
| Synonyms: | |
| 分子量: | 371.4337 |
| 分子式: | C19H25N5O3 |
| SMILES: | O=C(N1CCN(CC1)C2=C(N)N=NC(C3=CC=CC=C3O)=C2)OC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SGC-SMARCA-BRDVIII 是一种有效和选择性的SMARCA2/4和PB1(5)抑制剂，Kd值分别为 35 nM，36 nM 和 13 nM。SGC-SMARCA-BRDVIII 还抑制PB1(2)和PB1(3)，Kd值分别为 3.7 和 2.0 μM。SGC-SMARCA-BRDVIII 可以阻断 3T3-L1 鼠成纤维细胞的脂肪生成。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wanior, M., Preuss, F., Ni, X., et al.Pan-SMARCA/PB1 bromodomain inhibitors and their role in regulating adipogenesisJ. Med. Chem.63(23),14680-14699(2020)
