GNE-064
Cat. No.：YN310456
CAS No. ：1997321-20-6
| 产品名称: | GNE-064 |
| CAS No.: | 1997321-20-6 |
| Chemical Name: | |
| Synonyms: | GNE064;GTPL12206;BDBM394530;US10308614, Example 131;compound 5 [PMID: 35930799];(R)-1-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2-methylpiperazin-1-yl)ethan-1-one;1-[(2R)-4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-2-methylpiperazin-1-yl]ethanone;E |
| 分子量: | 327.38 |
| 分子式: | C17H21N5O2 |
| SMILES: | O=C(C([H])([H])[H])N1C([H])([H])C([H])([H])N(C2C(N([H])[H])=NN=C(C3=C([H])C([H])=C([H])C([H])=C3O[H])C=2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-064 (compound 5) 是一种选择性的，具有口服活性的以及高可溶性的SMARCA4，SMARCA2和PBRM1bromodomains 5 抑制剂。GNE-064 对 SMARCA4 具有抑制作用，其IC50值为 0.035 μM，对 SMARCA2 也具有抑制作用，其EC50值为 0.10 μM。GNE-064 对 SMARCA4，SMARCA2，PBRM1 bromodomains 5 和 PBRM1 bromodomains 2 的Kd值为 0.01，0.016，0.018 以及 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
