NSC 617145
Cat. No.：YN290673
CAS No. ：203115-63-3
| 产品名称: | NSC 617145 |
| CAS No.: | 203115-63-3 |
| Chemical Name: | 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione |
| Synonyms: | NSC617145,NSC-617145,NSC 617145,WRN inhibitor |
| 分子量: | 400 |
| 分子式: | C13H10Cl4N2O4 |
| SMILES: | CC(CN(C(C(Cl)=C1Cl)=O)C1=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC 617145 是一种选择性 werner 综合征解旋酶 (WRN) 解旋酶抑制剂，IC50值为 230 nM。NSC 617145 抑制 WRN ATPase，并诱导双链断裂 (DSB) 和染色体异常。NSC 617145 对 WRN 具有选择性，优于 BLM、FANCJ、ChlR1、RecQ 和 UvrD 解旋酶。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Aggarwal, M., Banerjee, T., Sommers, J.A., et al.Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathwayCancer Res.73(17),5497-5507(2013)
