AZ31
Cat. No.：YN290677
| 产品名称: | AZ31 |
| CAS No.: | 2088113-98-6 |
| Chemical Name: | |
| Synonyms: | GXC30M65XM;AZ31;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide;BDBM50459007;s8556;A16813;3-Quinolinecarboxamide, 6-(6-(methoxymethyl)-3-pyridinyl)-4-(((1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl)amino) |
| 分子量: | 420.5 |
| 分子式: | C24H28N4O3 |
| SMILES: | O1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])N([H])C1C(C(N([H])[H])=O)=C([H])N=C2C([H])=C([H])C(C3=C([H])N=C(C([H])([H])OC([H])([H])[H])C([H])=C3[H])=C([H])C=12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ31 是有效的、高选择性、具有口服活性的ATM的抑制剂，对ATM酶的IC50值 <1.2 nM，对细胞内ATM的IC50值为 46 nM。AZ31 表现出优异的ATR选择性 (>500 倍) 、PIKK 家族选择性和泛激酶选择性。AZ31 是一种强效的体外放射增敏剂，可用于癌症的研究。 |
| IC50和靶点: | [{name:"ATM:1.2 nM (IC50)"},{name: "ATM:46 nM (IC50, in cell)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
