MS049 dihydrochloride
Cat. No.：YN310466
| 产品名称: | MS049 dihydrochloride |
| CAS No.: | 2095432-59-8 |
| Chemical Name: | N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride |
| Synonyms: | |
| 分子量: | 321.3 |
| 分子式: | C15H24N2O • 2HCl |
| SMILES: | CNCCN(CC1)CCC1OCC2=CC=CC=C2.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MS049 dihydrochloride 是一种高效、选择性和细胞活性的PRMT4和PRMT6双重抑制剂，IC50分别为 34 nM 和 43 nM。MS049 dihydrochloride 降低了 HEK293 细胞的 Med12me2a 和 H3R2me2a 水平。MS049 dihydrochloride 对 HEK293 细胞无毒，并且没有影响其的生长。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Shen, Y., Szewczyk, M.M., Eram, M.S., et al.Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6J. Med. Chem.,(2016)
