CPTH2 hydrochloride
Cat. No.：YN310468
| 产品名称: | CPTH2 hydrochloride |
| CAS No.: | 2108899-91-6 |
| Chemical Name: | 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone, monohydrochloride |
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| 分子量: | 328.3 |
| 分子式: | C14H14ClN3S • HCl |
| SMILES: | ClC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC\3)=N2.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPTH2 hydrochloride 是有效的组蛋白乙酰基转移酶 (HAT) 抑制剂。CPTH2 hydrochloride 选择性地抑制Gcn5对组蛋白 H3 的乙酰化。CPTH2 hydrochloride 通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡 (apoptosis) 并降低透明细胞肾癌 (ccRCC) 细胞系的侵袭性。 |
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Chimenti, F., Bizzarri, B., Maccioni, E., et al.A novel histone acetyltransferase inhibitor modulating Gcn5 network: Cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazoneJ. Med. Chem.52,530-536(2009)
Ablack, J.N.G., Cohen, M., Thillainadesan, G., et al.Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivationJ. Virol.86(15),8198-8209(2012)
