Aminopurvalanol A
Cat. No.：YN290693
CAS No. ：220792-57-4
| 产品名称: | Aminopurvalanol A |
| CAS No.: | 220792-57-4 |
| Chemical Name: | (2R)-2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Synonyms: | |
| 分子量: | 403.9 |
| 分子式: | C19H26ClN7O |
| SMILES: | CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=CC(N)=C3)=C2N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aminopurvalanol A 是一种有效的、选择性的、可渗透细胞的Cyclins/Cdk复合物抑制剂。Aminopurvalanol A 优先靶向G2/M 期转变进而抑制癌细胞分化。Aminopurvalanol A 通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chang, Y.-T., Gray, N.S., Rosania, G.R., et al.Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitorsChem. Biol.6(6),361-375(1999)
Rosania, G.R., Merlie, J.J., Gray, N., et al.A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extractsProc. Natl. Acad. Sci. USA96(9),4797-4802(1999)
Knockaert, M., Gray, N., Damiens, E., et al.Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitorsChem. Biol.7(6),411-422(2000)
