Belotecan
Cat. No.：YN290695
| 产品名称: | Belotecan |
| CAS No.: | 22136-74-9 |
| Chemical Name: | 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
| Synonyms: | 竹柏双黄酮 A |
| 分子量: | 552.4845 |
| 分子式: | C31H20O10 |
| SMILES: | O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)O)=C(O)C=C2)OC6=C1C(O)=CC(O)=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Podocarpusflavone A是一个 DNAtopoisomeraseI 抑制剂，有一定的抗增殖能力，在 MCF-7 细胞中能引起凋亡，正在发展成抗肿瘤活性分子。 |
| IC50和靶点: | [{name:"Topoisomerase I:119.425 μM (IC50)"}] |
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| Solvent & Solubility: |
Zhang, Y., Tan, N.S., Huang, H., et al.Three bioactive biflavones isolated from Taxodium mucronatumYunnan Zhiwu Yanjiu27(1),107-110(2005)
Meng, H., Pang, Y., Liu, G., et al.Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signalingJ. Dermatol. Sci.100(3),201-208(2020)
Coulerie, P., Nour, M., Maciuk, A., et al.Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRpPlanta Med.79(14),1313-1318(2013)
Arwa, P.S., Zeraik, M.L., Ximenes, V.F., et al.Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damageJ. Ethnopharmacol.174,410-418(2015)
Sirimangkalakitti, N., Juliawaty, L.D., Hakim, E.H., et al.Naturally occurring biflavonoids with amyloid β aggregation inhibitory activity for development of anti-Alzheimer agentBioorg. Med. Chem. Lett.29(15),1994-1997(2019)
