GSK3368715 trihydrochloride
Cat. No.：YN310475
| 产品名称: | GSK3368715 trihydrochloride |
| CAS No.: | 2227587-26-8 |
| Chemical Name: | |
| Synonyms: | EPZ019997 trihydrochloride |
| 分子量: | 475.92 |
| 分子式: | C20H41Cl3N4O2 |
| SMILES: | Cl.Cl.Cl.CCOCC1(CCC(CC1)C2=N[NH]C=C2CN(C)CCNC)COCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK3368715 trihydrochloride (EPZ019997) 是具有口服活性的，可逆的，SAM 非竞争性 I 型蛋白精氨酸甲基转移酶(PRMTs)抑制剂 (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8))。GSK3368715 trihydrochloride (EPZ019997) 导致精氨酸甲基化状态的转变，改变了外显子的使用，具有很强的抗癌活性。 |
| IC50和靶点: | [{name:"PRMT4:1148 nM (IC50)"},{name: "PRMT3:48 nM (IC50)"},{name: "PRMT1:3.1 nM (IC50)"},{name: "PRMT6:5.8 nM (IC50)"},{name: "PRMT8:1.7 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
