CDK12-IN-2
Cat. No.：YN290700
CAS No. ：2244987-03-7
| 产品名称: | CDK12-IN-2 |
| CAS No.: | 2244987-03-7 |
| Chemical Name: | |
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| 分子量: | 532.64 |
| 分子式: | C32H32N6O2 |
| SMILES: | O=C(NCC1=CC=CC=C1)N(C2=CC=C(C(C=C3)=CN(C)C3=O)C=C2)[C@H]4CC[C@H](NC5=CC=C(C#N)C=N5)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CDK12-IN-2是一种高效、选择性的纳摩尔级别的CDK12抑制剂 (IC50=52 nM)，具有良好的物理化学性质。CDK12-IN-2也是一种强的CDK13抑制剂，因为CDK13是CDK12最接近的同源物。CDK12-IN-2对CDK12的激酶选择性比CDK2、9、8和7高。CDK12-IN-2抑制RNA polymerase II 的 C端Ser2磷酸化。CDK12-IN-2可以作为一种很好的化学探针用于CDK12的功能研究。 |
| IC50和靶点: | [{name:"CDK12:52 nM (IC50)"},{name: "CDK2:>100 μM (IC50)"},{name: "CDK7:>10 μM (IC50)"},{name: "CDK9:16 μM (IC50)"}] |
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