CAY10746
Cat. No.：YN290701
CAS No. ：2247240-76-0
| 产品名称: | CAY10746 |
| CAS No.: | 2247240-76-0 |
| Chemical Name: | 4-(dimethylamino)-N-[3-[[2-[(4-oxo-4H-1-benzopyran-7-yl)oxy]acetyl]amino]phenyl]-benzamide |
| Synonyms: | |
| 分子量: | 457.47804 |
| 分子式: | C26H23N3O5 |
| SMILES: | CN(C)C1=CC=C(C(NC2=CC=CC(NC(COC3=CC(OC=CC4=O)=C4C=C3)=O)=C2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAY10746 是一种选择性 Rho 激酶(ROCK)抑制剂。CAY10746 对ROCKI、ROCKII具有抑制活性，IC50值分别为 0.014 μM 和 0.003 μM。CAY10746 可用于糖尿病视网膜病变（DR）的研究。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Zhao, L., Li, Y., Wang, Y., et al.Discovery of 4H-chromen-4-one derivatives as a new class of selective Rho kinase (ROCK) inhibitors, which showed potent activity in ex vivo diabetic retinopathy modelsJ. Med. Chem.62(23),10691-10710(2019)
