Bobcat339
Cat. No.：YN310484
CAS No. ：2280037-51-4
| 产品名称: | Bobcat339 |
| CAS No.: | 2280037-51-4 |
| Chemical Name: | 4-amino-1-[1,1′-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone |
| Synonyms: | Bobcat339;BCP31159;1-([1,1'-Biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one |
| 分子量: | 297.7 |
| 分子式: | C16H12ClN3O |
| SMILES: | O=C1N=C(C(Cl)=CN1C2=CC=CC(C3=CC=CC=C3)=C2)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bobcat339 是一种有效的、选择性的基于胞嘧啶的TET酶抑制剂，抑制TET1和TET2的IC50值分别为 33 μM 和 73 μM。Bobcat339 可用于表观遗传学领域研究，并且可作为靶向 DNA 甲基化和基因转录新疗法的起点。 |
| IC50和靶点: | [{name:"TET1:33 μM (IC50)"},{name: "TET2:73 μM (IC50)"}] |
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| Solvent & Solubility: |
Chua, G.N.L., Wassarman, K.L., Sun, H., et al.Cytosine-based TET enzyme inhibitorsACS Med. Chem. Lett.10(2),180-185(2019)
Weirath, N.A., Hurben, A.K., Chao, C., et al.Small molecule inhibitors of TET dioxygenases: Bobcat339 activity is mediated by contaminating copper(II)ACS Med. Chem. Lett.13(5),792-798(2022)
