3-Deazauridine
Cat. No.：YN290708
CAS No. ：23205-42-7
| 产品名称: | 3-Deazauridine |
| CAS No.: | 23205-42-7 |
| Chemical Name: | 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone |
| Synonyms: | NSC 126849 |
| 分子量: | 243.2 |
| 分子式: | C10H13NO6 |
| SMILES: | O=C(C=C(O)C=C1)N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Deazauridine (NSC 126849) 是一种尿苷类似物。3-Deazauridine 可竞争性抑制三磷酸胞苷合成酶来抑制胞苷-5’-三磷酸的生物合成。3-Deazauridine 与多种抗肿瘤试剂具有协同作用，作为一种生物反应调节剂。 |
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Moriconi, W.J., Slavik, M., and Taylor, S.3-Deazauridine (NSC 126849): An interesting modulator of biochemical responseInvest New Drugs4(1),67-84(1986)
Bloch, A., Dutschman, G., Currie, B.L., et al.Preparation and biological activity of various 3-deazapyrimidines and related nucleosidesJ. Med. Chem.16(3),294-297(1973)
Raynal, N.J.-M., Momparler, L.F., Rivard, G.E., et al.3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinaseLeuk. Res.35(1),110-118(2011)
