EML741
Cat. No.：YN310485
| 产品名称: | EML741 |
| CAS No.: | 2328074-38-8 |
| Chemical Name: | |
| Synonyms: | T11185;EML741 |
| 分子量: | 523.75 |
| 分子式: | C31H49N5O2 |
| SMILES: | N1C2=CC(OCCCN3CCCC3)=C(OC)C=C2C(NC2CCN(C(C)C)CC2)=NCC=1C1CCCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EML741 是一种组蛋白甲基转移酶 (G9a/GLP) 抑制剂，对 G9a 的IC50和Kd值分别为 23 nM 和 1.13 μM。EML741 可抑制DNMT1(IC50，3.1 μM)，但对 DNMT3a 或 DNMT3b 无作用。EML741 具有低细胞毒性，同时表现出良好的膜透过性和血脑屏障透过性。 |
| IC50和靶点: | [{name:"G9a:23 nM (IC50)"},{name: "G9a:1.13 μM (Kd)"},{name: "DNMT1:3.1 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
