BAY-3827
Cat. No.:YN310488
CAS No. :2377576-35-5
产品名称: | BAY-3827 |
CAS No.: | 2377576-35-5 |
Chemical Name: | |
Synonyms: | |
分子量: | 468.53 |
分子式: | C27H25FN6O |
SMILES: | CCC1=CC=CC=C1C(=O)NC2=N[NH]C3=C2C=C(C4C(=C(C)N(C)C(=C4C#N)C)C#N)C(=C3C)F |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | BAY-3827 是强效的、选择性的AMPK抑制剂,IC50值为 1.4 nM (10 µM ATP) 和 15 nM (2 mM ATP)。BAY-3827 对其他 331 种被测激酶的选择性超过 500 倍相比于AMPK。AMPK 抑制乙酰 CoA 羧化酶 1 的磷酸化,并在雄激素依赖的前列腺癌细胞株中显示出强效的抗增殖活性。 |
IC50和靶点: | |
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Clinical Trial: | |
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