SCR130
Cat. No.：YN290715
CAS No. ：2377858-38-1
| 产品名称: | SCR130 |
| CAS No.: | 2377858-38-1 |
| Chemical Name: | 2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione |
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| 分子量: | 418.29694 |
| 分子式: | C19H13Cl2N3O2S |
| SMILES: | O=C1NC(NC(C12N=C(CC2C3=CC=C(C=C3)Cl)C4=CC=C(Cl)C=C4)=O)=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SCR130 是一种基于 SCR7 的 DNA 非同源末端连接 (NHEJ) 抑制剂。SCR130 以依赖连接酶 IV 的方式抑制 DNA 的末端连接。SCR130 对连接酶 IV 具有特异性，对连接酶 III 和连接酶 I 介导的连接的影响很小或没有影响。SCR130 诱导细胞凋亡 (apoptosis)，并具有抗癌活性。 |
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Ray, U., Raul, S.K., Gopinatha, V.K., et al.Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeuticsMol. Carcinog.59(6),618-628(2020)
