WDR5-IN-1
Cat. No.：YN310492
| 产品名称: | WDR5-IN-1 |
| CAS No.: | 2408842-51-1 |
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| 分子量: | 514.59 |
| 分子式: | C30H31FN4O3 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WDR5-IN-1 是一种有效的选择性 WD 重复结构域 5(WDR5)抑制剂，Kd为 <0.02 nM。WDR5-IN-1 抑制 MLL1 组蛋白甲基转移酶活性 (HMT)，IC50为 2.2 nM。WDR5-IN-1 减少 WDR5 移位基因的 MYC 募集，并在 CHP-134 (神经母细胞瘤) 和 Ramos (Burkitt淋巴瘤) 细胞系中显示出有效的抗增殖作用。 |
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