Palmitic acid-
Cat. No.：YN290719
CAS No. ：2411429-33-7
| 产品名称: | Palmitic acid- |
| CAS No.: | 2411429-33-7 |
| Chemical Name: | 5-methoxy-N-[3-methoxy-4-[2-(2-piperidinyl)ethoxy]phenyl]-2,2-dimethyl-2H-1-benzopyran-6-carboxamide |
| Synonyms: | |
| 分子量: | 466.56934 |
| 分子式: | C27H34N2O5 |
| SMILES: | O=C(C1=CC=C2OC(C)(C)C=CC2=C1OC)NC3=CC=C(C(OC)=C3)OCCC4NCCCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NCT-58是HSP90C末端的有效抑制剂。NCT-58 不诱导热休克反应 (HSR)，因为它靶向 C 末端区域，并通过同时下调 HER 家族成员以及抑制Akt磷酸化来引发抗肿瘤活性。NCT-58 可杀死曲妥珠单抗耐药 (Trastuzumab-resistant) 的乳腺癌干细胞样细胞。NCT-58 诱导 HER2 阳性乳腺癌细胞凋亡。在抗曲妥珠单抗异种移植模型中，NCT-58 可抑制生长和血管生成。 |
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Park, S., Kim, Y.-J., Park, J.M., et al.The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cellsCell Death Discov.7(1),354(2021)
Nguyen, C.-T., Ann, J., Sahu, R., et al.Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90)Bioorg. Med. Chem. Lett.30(17),127374(2020)
