G6PDi-1
Cat. No.：YN290723
CAS No. ：2457232-14-1
| 产品名称: | G6PDi-1 |
| CAS No.: | 2457232-14-1 |
| Chemical Name: | 4-((5-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile |
| Synonyms: | |
| 分子量: | 284.33744 |
| 分子式: | C14H12N4OS |
| SMILES: | O=C(CCCC1)C2=C1N=C(NC3=CSC(C#N)=C3)N=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | G6PDi-1 是一种可逆的非竞争性6-磷酸葡萄糖脱氢酶 (G6PD) 抑制剂，IC50为 0.07 μM。G6PDi-1 最强烈地消耗淋巴细胞中的 NADPH。G6PDi-1 显着降低 T 细胞中炎性细胞因子的产生。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ghergurovich, J.M., García-Cañaveras, J.C., Wang, J., et al.A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathwayNat. Chem. Biol.16(7),731-739(2020)
