NN-390
Cat. No.：YN290724
| 产品名称: | NN-390 |
| CAS No.: | 2490284-25-6 |
| Chemical Name: | N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-benzamide |
| Synonyms: | NN 390 |
| 分子量: | 420.3796328 |
| 分子式: | C17H16F4N2O4S |
| SMILES: | O=C(C1=CC=C(CN(S(=O)(C2=CC(F)=C(C(F)=C2F)F)=O)C(C)C)C=C1)NO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NN-390 是一种有效的选择性HDAC6抑制剂，其IC50为 9.8 nM。NN-390 可穿透血脑屏障。NN-390 在转移性第 3 组成神经管细胞瘤中显示出研究潜力。 |
| IC50和靶点: | [{name:"HDAC2:>5 μM (IC50)"},{name: "HDAC1:>5 μM (IC50)"},{name: "HDAC6:9.8 nM (IC50)"},{name: "HDAC3:>1 μM (IC50)"},{name: "HDAC8:>1 μM (IC50)"},{name: "HDAC11:>1 μM (IC50)"}] |
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Nawar, N., Bukhari, S., Adile, A.A., et al.Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastomaJ. Med. Chem.65(4),3193-3217(2022)
