Saruparib
Cat. No.：YN290728
| 产品名称: | Saruparib |
| CAS No.: | 2589531-76-8 |
| Chemical Name: | 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide |
| Synonyms: | AZD5305 |
| 分子量: | 406.48108 |
| 分子式: | C22H26N6O2 |
| SMILES: | O=C(C1=NC=C(N2CCN(CC2)CC3=CC4=C(C=C(CC)C(N4)=O)N=C3)C=C1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Saruparib (AZD5305) 是一种口服有效的，具有选择性的多聚 ADP 核糖聚合酶抑制剂和捕集剂，对PARP1和PARP2的IC50值分别为 3 nM 和 1400 nM。Saruparib 具有抗增殖活性，并抑制 DNA 修复缺陷细胞的生长。 |
| IC50和靶点: | [{name:"PARP1:3 nM (IC50)"},{name: "PARP2:1400 nM (IC50)"}] |
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Johannes, J.W., Balazs, A., Barratt, D., et al.Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1—DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPsJ. Med. Chem.64(19),14498-14512(2021)
