MRTX-1719
Cat. No.：YN310501
| 产品名称: | MRTX-1719 |
| CAS No.: | 2630904-45-7 |
| Chemical Name: | |
| Synonyms: | 2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-4-chloro-6-cyclopropyloxy-3-fl |
| 分子量: | 464.8794 |
| 分子式: | C23H18ClFN6O2 |
| SMILES: | ClC1=C(C(C2=C(C([H])=NN2C([H])([H])[H])C2C([H])=C([H])C3C(N([H])N=C(C([H])([H])N([H])[H])C=3C=2[H])=O)=C(C#N)C(=C1[H])OC1([H])C([H])([H])C1([H])[H])F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MRTX-1719 是一种有效的，具有口服活性，选择性的PRMT5•MTA复合物抑制剂，对PRMT5•MTA和PRMT5的IC50分别为 3.6 和 20.5 nM。MRTX-1719 可以与PRMT5•MTA复合物结合，KD值为 0.14 pM。MRTX-1719 在体内外显示出抗肿瘤活性，可用于癌症研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
