Ryuvidine
Cat. No.：YN290732
| 产品名称: | Ryuvidine |
| CAS No.: | 265312-55-8 |
| Chemical Name: | 2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione |
| Synonyms: | |
| 分子量: | 284.3 |
| 分子式: | C15H12N2O2S |
| SMILES: | CC1=CC=C(NC2=CC(C(SC(C)=N3)=C3C2=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ryuvidine 是一种含有的 SET 结构域的蛋白质 8 (SETD8) 的有效抑制剂，其IC50为 0.5 µM，并在体外抑制 H4K20的甲基化。Ryuvidine 还抑制CDK4，IC50为 6.0 μM，并对一系列人类癌细胞具有细胞毒性。 |
| IC50和靶点: | [{name:"CDK4:6.0 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Blum, G., Ibáñez, G., Rao, X., et al.Small-molecule inhibitors of SETD8 with cellular activityACS Chem. Biol.9(11),2471-2478(2014)
Ryu, C.K., Kang, H.Y., Lee, S.K., et al.5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agentsBioorg. Med. Chem. Lett.10,461-464(2000)
FitzGerald, J., Murillo, L.S., O'Brien, G., et al.A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage responsePLoS One9(6),(2014)
