SP-96
Cat. No.：YN290735
CAS No. ：2682114-54-9
| 产品名称: | SP-96 |
| CAS No.: | 2682114-54-9 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 453.47 |
| 分子式: | C25H20FN7O |
| SMILES: | CC1N=CC(=N1)C2=CC=C3C(=NC=NC3=C2)NC4=CC=CC(=C4)NC(=O)NC5=CC(=CC=C5)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SP-96 是一种高效、选择性和 ATP 竞争性Aurora B抑制剂，IC50为 0.316 nM，对FLT3和 KIT 具有 >2000 倍选择性。SP-96 在 NCI60 筛选中表现出选择性生长抑制，对 MDA-MD-468 等乳腺癌细胞具有选择性 (GI50=107 nM)。SP-96 可用于三阴性乳腺癌 (TNBC) 的相关研究。 |
| IC50和靶点: | [{name:"Aurora A:18.975 nM (IC50)"},{name: "Aurora B:0.316 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
