(5E,9E,13E)-Teprenone
Cat. No.：YN290738
| 产品名称: | (5E,9E,13E)-Teprenone |
| CAS No.: | 2753-30-2 |
| Chemical Name: | (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyl-oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione |
| Synonyms: | |
| 分子量: | 482.6 |
| 分子式: | C28H34O7 |
| SMILES: | O=C1[C@@H]2[C@]3(O2)[C@]4(C)[C@H](OC(C)=O)C[C@@]5([H])C(C)(C)C(C=C[C@]5(C)[C@@]4([H])CC[C@@]3(C)[C@H](C6=COC=C6)O1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gedunin 是一种具有抗癌、抗病毒、抗炎和杀虫活性的化合物。Gedunin 作为一种有效的Hsp90抑制剂，诱导Hsp90依赖的蛋白的降解。Gedunin 可阻断 SARS-CoV-2 病毒进入人宿主细胞，可用于 COVID-19 研究。 |
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Tharmarajah, L., Samarakoon, S.R., Ediriweera, M.K., et al.In vitro anticancer effect of gedunin on human teratocarcinomal (NTERA-2) cancer stem-like cellsBiomed. Res. Int.2017,2413197(2017)
Patwardhan, C.A., Fauq, A., Peterson, L.B., et al.Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosisJ. Biol. Chem.288(10),7313-7325(2013)
Brandt, G.E.L., Schmidt, M.D., Prisinzano, T.E., et al.Gedunin, a novel hsp90 inhibitor: Semisynthesis of derivatives and preliminary structure-activity relationshipsJ. Med. Chem.51(20),6495-6502(2008)
Subramani, R., Gonzalez, E., Nandy, S.B., et al.Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathwayOncotarget8(7),10891-10904(2017)
Conte, F.P., Kerraris, F.K., Costa, T.E.M.M., et al.Effect of gedunin on acute articular inflammation and hypernociception in miceMolecules20(2),2636-2657(2015)
Ferraris, F.K., Moret, K.H., Figueiredo, A.B.C., et al.Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammationInt. Immunopharmacol.14(1),82-93(2012)
Borges, P.V., Moret, K.H., Maya-Monteiro, C.M., et al.Gedunin binds to myeloid differentiation protein 2 and impairs lipopolysaccharide-induced toll-like receptor 4 signaling in macrophagesMol. Pharm.88(5),949-961()
