DR2313
Cat. No.：YN290743
CAS No. ：284028-90-6
| 产品名称: | DR2313 |
| CAS No.: | 284028-90-6 |
| Chemical Name: | 3,5,7,8-tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Synonyms: | |
| 分子量: | 182.2 |
| 分子式: | C8H10N2OS |
| SMILES: | O=C(N=C(C)N1)C2=C1CCSC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DR2313 是一种有效，选择性，竞争性的和可透过血脑屏障的PARP抑制剂，抑制PARP-1和PARP-2的IC50值分别为 0.20 μM 和 0.24 μM。DR2313 在体外和体内均表现出对缺血性损伤的神经保护作用。 |
| IC50和靶点: | [{name:"PARP-1:0.20 μM (IC50)"},{name: "PARP-2:0.24 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Nakajima, H., Kakuki, N., Ohkuma, K., et al.A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: Pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in ratsJ. Pharmacol. Exp. Ther.312(2),472-481(2005)
Xu, Z., Zhang, J., David, K.K., et al.Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemiaAm. J. Physiol. Regul. Integr. Comp. Physiol.299(1),R215-R221(2010)
