α-Hydroxyglutaric acid
Cat. No.：YN310506
CAS No. ：2889-31-8
| 产品名称: | α-Hydroxyglutaric acid |
| CAS No.: | 2889-31-8 |
| Chemical Name: | 2-hydroxy-pentanedioic acid |
| Synonyms: | 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid |
| 分子量: | 148.11402 |
| 分子式: | C5H8O5 |
| SMILES: | OC(C(CCC(O)=O)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid 是多种 α-酮戊二酸依赖性双加氧酶 (包括histone demethylases和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。 |
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Rzem, R., Veiga-da-Cunha, M., Noël, G., et al.A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduriaProc. Natl. Acad. Sci. USA101(48),16849-16854(2004)
Struys, E.A., Verhoeven, N.M., Roos, B., et al.Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduriaClin. Chem.49(7),1133-1138(2003)
Struys, E.A., Salomons, G.S., Achouri, Y., et al.Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduriaAm. J. Hum. Genet.76(2),358-360(2005)
Ward, P., Patel, J., Wise, D.R., et al.The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarateCancer Cell17(3),225-234(2010)
Yang, H., Ye, D., Guan, K.L., et al.IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectivesClin. Cancer Res.18(20),5562-5571(2012)
Xu, W., Yang, H., Liu, Y., et al.Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesCancer Cell19(1),17-30(2011)
Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al.The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesEMBO Rep.12(5),463-469(2011)
