(S)-Coriolic acid
Cat. No.：YN290746
CAS No. ：29623-28-7
| 产品名称: | (S)-Coriolic acid |
| CAS No.: | 29623-28-7 |
| Chemical Name: | 13S-hydroxy-9Z,11E-octadecadienoic acid |
| Synonyms: | 13(S |
| 分子量: | 296.5 |
| 分子式: | C18H32O3 |
| SMILES: | CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-Coriolic acid (13(S)-HODE) ，亚油酸的15-脂氧合酶 (15-LOX) 代谢产物，作为内源性配体激活PPARγ。(S)-Coriolic acid 是一种重要的细胞内信号剂，在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 诱导线粒体功能障碍 (mitochondrial dysfunction) 和气道上皮损伤。 |
| IC50和靶点: | |
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Buchanan, M.R., Haas, T.A., Lagarde, M., et al.13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOXJ. Biol. Chem.260(30),16056-16059(1985)
Honn, K.V., Nelson, K.K., Renaud, C., et al.Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasisProstaglandins44(5),413-429(1992)
Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al.Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acidCancer Res.49(4),1029-1037(1989)
