BRD9876
Cat. No.：YN290753
| 产品名称: | BRD9876 |
| CAS No.: | 32703-82-5 |
| Chemical Name: | 6-(1,1-dimethylethyl)-2,3-naphthalenedicarbonitrile |
| Synonyms: | BRD9876 |
| 分子量: | 234.29584 |
| 分子式: | C16H14N2 |
| SMILES: | N#CC1=CC2=CC=C(C(C)(C)C)C=C2C=C1C#N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD9876 是一种 “rigor” 抑制剂，可将驱动蛋白 5 (Eg5) 锁定在增强微管 (MTs) 结合的状态，从而导致 MT 的捆绑和稳定。BRD9876 与酪氨酸 104 残基相互作用，该残基是 α4-α6 变构结合口袋的一部分。BRD9876 特异性靶向微管结合的 Eg5，选择性抑制CD34细胞的骨髓瘤。BRD9876 具有用于多发性骨髓瘤 (MM) 研究的潜力。 |
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Chattopadhyay, S., Stewart, A.L., Mukherjee, S., et al.Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitorsCell Rep.10(5),755-770(2015)
