Muraglitazar
Cat. No.：YN290755
| 产品名称: | Muraglitazar |
| CAS No.: | 331741-94-7 |
| Chemical Name: | N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-glycine |
| Synonyms: | BMS-298585 |
| 分子量: | 516.5 |
| 分子式: | C29H28N2O7 |
| SMILES: | O=C(OC1=CC=C(OC)C=C1)N(CC(O)=O)CC2=CC=C(C=C2)OCCC3=C(C)OC(C4=CC=CC=C4)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Muraglitazar是一种PPARα/γ的双激动剂，用于研究 2 型糖尿病及相关血脂异常。Muraglitazar对人PPARα (EC50= 320 nM)和PPARγ(EC50= 110 nM)具有较强的体外活性。 |
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Devasthale, P.V., Chen, S., Jeon, Y., et al.Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor α/γ dual agonist with efficacious glucose and lipid-lowering activitiesJ. Med. Chem.48,2248-2250(2005)
Rogue, A., Anthérieu, S., Vluggens, A., et al.PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cellsToxicol. Appl. Pharmacol.276(1),73-81(2014)
Harrity, T., Farrelly, D., Tieman, A., et al.Muraglitazar, a novel dual (α/γ) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves β-cell function in db/db miceDiabetes55(1),240-248(2006)
Paukkeri, E.-L., Leppänen, T., Lindholm, M., et al.Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo modelsArthritis Res. Ther.15(2):R51,(2013)
