8-Chloroadenosine
Cat. No.：YN310508
| 产品名称: | 8-Chloroadenosine |
| CAS No.: | 34408-14-5 |
| Chemical Name: | 8-chloro-adenosine |
| Synonyms: | 8-氯腺嘌呤核苷; 8-Cl-Ado |
| 分子量: | 301.68628 |
| 分子式: | C10H12ClN5O4 |
| SMILES: | ClC(N([C@]1([H])O[C@@H]([C@H]([C@H]1O)O)CO)C2=NC=N3)=NC2=C3N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-Chloroadenosine (8-Cl-Ado) 是一种独特的核糖核苷类似物，可消耗内源性 ATP，随后诱导AMPK的磷酸化和活化。8-Chloroadenosine 诱导自噬细胞死亡。8-Chloroadenosine 可有效抑制小鼠体内肿瘤生长。 |
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Gandhi, V., Ayres, M., Halgren, R.G., et al.8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cellsCancer Res.61(14),5474-5479(2001)
Carlson, C.C., Chinery, R., Burnham, L.L., et al.8-Cl-adenosine-induced inhibition of colorectal cancer growth in vitro and in vivoNeoplasia2(5),441-448(2000)
