Fmoc-leucine
Cat. No.：YN290759
| 产品名称: | Fmoc-leucine |
| CAS No.: | 35661-60-0 |
| Chemical Name: | N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine |
| Synonyms: | N-FMOC-leucine; NPC 15199; NSC 334290 |
| 分子量: | 353.4 |
| 分子式: | C21H23NO4 |
| SMILES: | CC(C)C[C@H](NC(=O)OCC1c2ccccc2c2ccccc12)C(=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fmoc-leucine 是一种选择性的PPARγ调节剂。与罗格列酮相比，Fmoc-leucine 激活PPARγ的效力较低，但最大效应相似。Fmoc-leucine 改善正常、饮食诱导的葡萄糖不耐受和糖尿病 db/db 小鼠的胰岛素敏感性。Fmoc-leucine 具有较低的诱导脂肪生成活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Heikkinen, S., Auwerx, J., and Argmann, C.A.PPARγ in human and mouse physiologyBiochim. Biophys. Acta1771(8),999-1013(2007)
Villacorta, L., Schopfer, F.J., Zhang, J., et al.PPARγ and its ligands: Therapeutic implications in cardiovascular diseaseClin. Sci. (Lond.)116(3),205-218(2009)
Zieleniak, A., Wójcik, M., and Wozniak, L.A.Structure and physiological functions of the human peroxisome proliferator-activated receptor γArch. Immunol. Ther. Exp. (Warsz.)56(5),331-345(2008)
Rocchi, S., Picard, F., Vamecq, J., et al.A unique PPARγ ligand with potent insulin-sensitizing yet weak adipogenic activityMol. Cell8(4),737-747(2001)
