Pemetrexed disodium heptahydrate
Cat. No.：YN290760
| 产品名称: | Pemetrexed disodium heptahydrate |
| CAS No.: | 357166-29-1 |
| Chemical Name: | N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt, heptahydrate |
| Synonyms: | LY231514 disodium heptahydrate |
| 分子量: | 597.5 |
| 分子式: | C20H19N5O6 • 2Na [7H2O] |
| SMILES: | O=C(N[C@H](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1CCC2=CNC(NC(N)=N3)=C2C3=O.[Na+].[Na+].O.O.O.O.O.O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pemetrexed disodium heptahydrate 是一种叶酸拮抗剂 (antifolate)。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki分别为 1.3 nM，7.2 nM 和 65 nM。 |
| IC50和靶点: | |
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Shih, C., Chen, V.J., Gossett, L.S., et al.LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymesCancer Res.57(6),1116-1123(1997)
Hanauske, A.R., Chen, V., Paoletti, P., et al.Pemetrexed disodium: A novel antifolate clinically active against multiple solid tumorsOncologist6(4),363-373(2001)
Takezawa, K., Okamoto, I., Okamoto, W., et al.Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancerBr. J. Cancer104(10),1594-1601(2011)
