Maytansine
Cat. No.：YN290761
| 产品名称: | Maytansine |
| CAS No.: | 35846-53-8 |
| Chemical Name: | MTS; Maitansine; Maysanine; Maytansin; N-Acetyl-N-methyl-L-alanine [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),1 |
| Synonyms: | NSC 153858 |
| 分子量: | 692.19596 |
| 分子式: | C34H46ClN3O10 |
| SMILES: | C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)\C)OC)(NC(O3)=O)O)C)([H])O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Maytansine 是一种高效的微管靶向化合物，可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。 |
| IC50和靶点: | |
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Wolpert-Defilippes, M.K., Adamson, R.H., Cysyk, R.L., et al.Initial studies on the cytotoxic action of maytansine, a novel ansa macrolideBiochem. Pharmacol.24(6),751-754(1975)
Luduena, R.F., Anderson, W.H., Prasad, V., et al.Interactions of vinblastine and maytansine with tubulinAnn. N. Y. Acad. Sci.466,718-732(1986)
Yaghoubi, S., Karimi, M.H., Lotfinia, M., et al.Potential drugs used in the antibody-drug conjugate (ADC) architecture for cancer therapyJ. Cell Physiol.235(1),31-64(2020)
