PIK-75
Cat. No.：YN290766
| 产品名称: | PIK-75 |
| CAS No.: | 372196-67-3 |
| Chemical Name: | 2-Methyl-5-nitro-benzenesulfonic Acid 2-[(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide; |
| Synonyms: | PIK-75,PIK 75,PIK75 |
| 分子量: | 452.28 |
| 分子式: | C16H14BrN5O4S |
| SMILES: | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C\\C2=CN=C3N2C=C(C=C3)Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIK-75 是一种可逆的DNA-PK和p110α-选择性的抑制剂，抑制DNA-PK，p110α 和 p110γ，IC50分别为 2，5.8 和 76 nM。PIK-75 抑制 p110α 效果比抑制 p110β (IC50=1.3 μM) 高 200 多倍。PIK-75 诱导凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"DNA-PK:2 nM (IC50)"},{name: "p110α:5.8 nM (IC50)"},{name: "p110γ:76 nM (IC50)"},{name: "p110δ:510 nM (IC50)"},{name: "p110β:1.3 μM (IC50)"},{name: "hsVPS34:2.6 μM (IC50)"},{name: "PI3KC2β:1 μM (IC50)"},{name: "PI3KC2α:10 μM (IC50)"},{name: "mTORC1:1 μM (IC50)"},{name: "mTORC2:10 μM (IC50)"},{name: "ATM:2.3 μM (IC50)"},{name: "ATR:21 μM (IC50)"},{name: "PI4KIIIβ:50 μM (IC50)"}] |
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| Solvent & Solubility: |
Zheng, Z., et al.: Mol. Pharmacol., 80, 657 (2011)
Moir, L., et al.: J. Pharmacol. Exp. Ther., 337, 557 (2011)
Jude, J., et al.: Am. J. Respir. Cell. Mol. Biol., 65, 2011
