RHPS4
Cat. No.：YN290769
CAS No. ：390362-78-4
| 产品名称: | RHPS4 |
| CAS No.: | 390362-78-4 |
| Chemical Name: | 3,11-difluorohydro-6,8,13-trimethyl-quino[4,3,2-kl]acridinium, methyl sulfate |
| Synonyms: | NSC714187 |
| 分子量: | 458.4787864 |
| 分子式: | C22H17F2N2 • CH3SO4 |
| SMILES: | FC1=CC=C(N(C)C2=CC(C)=CC3=C(C=C(F)C=C4)C4=[N+](C)C5=C23)C5=C1.O=S(OC)([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RHPS4 是有效的端粒酶 (telomerase) 抑制剂 (IC50= 0.33 μM)。RHPS4 是 DNA 损伤的诱导剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gowan, S.M., Heald, R., Stevens, M.F.G., et al.Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexesMol. Pharmacol.60(5),981-988(2001)
Ma, Y., Iida, K., and Nagasawa, K.Topologies of G-quadruplex: Biological functions and regulation by ligandsBiochem. Biophys. Res. Commun.531(1),3-17(2020)
Salvati, E., Leonetti, C., Rizzo, A., et al.Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectJ. Clin. Invest.117(11),3236-3247(2007)
Heald, R.A., Modi, C., Cookson, J.C., et al.Antitumor polycyclic acridines. 8.1 Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium saltsJ. Med. Chem.45(3),590-597(2002)
Leonetti, C., Amodei, S., D'Angelo, C., et al.Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alterationMol. Pharmacol.66(5),1138-1146(2004)
Leonetti, C., Scarsella, M., Riggio, G., et al.G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumorsClin. Cancer Res.14(22),7284-7291(2008)
