NSC693868
Cat. No.：YN290770
| 产品名称: | NSC693868 |
| CAS No.: | 40254-90-8 |
| Chemical Name: | 1H-pyrazolo[3,4-b]quinoxalin-3-amine |
| Synonyms: | |
| 分子量: | 185.2 |
| 分子式: | C9H7N5 |
| SMILES: | NC1=NNC2=NC3=C(N=C21)C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC693868 是一种选择性的CDK1和CDK5抑制剂，IC50s分别为 600 nM 和 400 nM。NSC693868 对 GSK3β 也有较弱的抑制作用，IC50为 1 µM，且不影响细胞分裂周期因子25 (CDC25) 活性。NSC693868 用于研究CDK1和CDK5在各种信号通路中的作用。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:600 nM (IC50)"},{name: "Cdk5/p25:400 nM (IC50)"},{name: "GSK-3β:1 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Ortega, M.A., Montoya, M.E., Zarranz, B., et al.Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitorsBioorg. Med. Chem.10(7),2177-2184(2002)
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Nguyen, T.K., and Grant, S.Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanismMol. Cancer Ther.13(3),662-674(2014)
Topanurak, S., Ferraris, J.D., Li, J., et al.High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesteraseProc. Natl. Acad. Sci. USA110(18),7482-7487(2013)
