Eeyarestatin I
Cat. No.：YN290772
| 产品名称: | Eeyarestatin I |
| CAS No.: | 412960-54-4 |
| Chemical Name: | 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl] hydroxyamino]-5,5-dimethyl-2-oxo-1- imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide |
| Synonyms: | |
| 分子量: | 630.4 |
| 分子式: | C27H25Cl2N7O7 |
| SMILES: | O=C1N(CC(N/N=C/C=C/C2=CC=C([N+]([O-])=O)O2)=O)C(C)(C)C(N(C(NC3=CC=C(Cl)C=C3)=O)O)N1C4=CC=C(Cl)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Eeyarestatin I 是一种有效的内质网相关蛋白降解 (ERAD) 抑制剂，是一种有效的蛋白易位抑制剂。Eeyarestatin I 抑制Sec61转位子。Eeyarestatin I 靶向与p97相关的去泛素化过程 (PAD)，并抑制依赖于 atx3 的去泛素化。Eeyarestatin I 在蛋白酶体降解前一步进行干扰。Eeyarestatin I 可防止 Sec61 蛋白易位。Eeyarestatin I 通过促凋亡蛋白 NOXA 诱导细胞死亡，并具有抗癌作用。 |
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Fiebiger, E., Hirsch, C., Vyas, J.M., et al.Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatinMol. Biol. Cell15(4),1635-1646(2004)
Wang, Q., Li, L., and Ye, Y.Inhibition of p97-dependent protein degradation by Eeyarestatin IJ. Biol. Chem.283(12),7445-7454(2008)
Wang, Q., Shinkre, B.A., Lee, J.G., et al.The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory groupPLoS One5(11),1-12(2010)
Aletrari, M.O., McKibbin, C., Williams, H., et al.Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathwaysPLoS One6(7),1-11(2011)
