TIQ-A
Cat. No.：YN290773
| 产品名称: | TIQ-A |
| CAS No.: | 420849-22-5 |
| Chemical Name: | thieno[2,3-c]isoquinolin-5(4H)-one |
| Synonyms: | |
| 分子量: | 201.2 |
| 分子式: | C11H7NOS |
| SMILES: | O=C1NC2=C(C=CS2)C3=C1C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TIQ-A 是一种有效TNKS(poly-ART, PARP) 抑制剂，其对TNKS2的IC50为 24 nM。TIQ-A 是一种潜在的抗缺血性活性分子。 |
| IC50和靶点: | [{name:"TNKS2:24 nM (IC50)"},{name: "PARP2:210 nM (IC50)"},{name: "PARP15:230 nM (IC50)"},{name: "PARP10:>10 μM (IC50)"},{name: "PARP14:>10 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chiagurgi, A., Meli, E., Calvani, M., et al.Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: Pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemiaJ. Pharmacol. Exp. Ther.305(5),943-949(2014)
Oumouna, M., Datta, R., Oumouna-Benachour, K., et al.Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: A potential specific effect on IL-5J. Immunol.177(9),6489-6496(2006)
Hans, C.P., Zerfaoui, M., Naura, A.S., et al.Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: Effects on inflammatory markers and lipid contentJ. Pharmacol. Exp. Ther.329(1),150-158(2009)
