BRD32048
Cat. No.：YN290775
CAS No. ：433694-46-3
| 产品名称: | BRD32048 |
| CAS No.: | 433694-46-3 |
| Chemical Name: | N2-(4-methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine |
| Synonyms: | |
| 分子量: | 314.4 |
| 分子式: | C16H22N6O |
| SMILES: | COC1=CC=C(C=C1)NC2=NC(CN3CCCCC3)=NC(N)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD32048 是ETV1的直接结合剂，KD为 17.1 μM。BRD32048 调节 ETV1 介导的转录活性和 ETV1 驱动的癌细胞侵袭。BRD32048 抑制 ETV1 乙酰化并促进其降解。BRD32048 是最佳候选 ETV1 干扰素。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Oh, S., Shin, S., and Janknecht, R.ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factorsBiochim. Biophys. Acta1826(1),1-12(2012)
Pop, M.S., Stransky, N., Garvie, C.W., et al.A small molecule that binds and inhibits the ETV1 transcription factor oncoproteinMol. Cancer Ther.13(6),1492-1502(2014)
