NU6102
Cat. No.：YN290776
CAS No. ：444722-95-6
| 产品名称: | NU6102 |
| CAS No.: | 444722-95-6 |
| Chemical Name: | 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-benzenesulfonamide |
| Synonyms: | NU6102;NU 6102 |
| 分子量: | 402.5 |
| 分子式: | C18H22N6O3S |
| SMILES: | NS(C(C=C1)=CC=C1NC2=NC(NC=N3)=C3C(OCC4CCCCC4)=N2)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NU6102 是一种有效的CDK1和CDK2抑制剂，对CDK1/cyclinB和CDK2/cyclinA3的IC50分别为 9.5 nM 和 5.4 nM。NU6102 对CDK1/CDK2的选择性比对CDK4(IC50为 1.6 μM)，DYRK1A (IC50为 0.9 μM)，PDK1 (IC50为 0.8 μM) 和 ROCKII (IC50为 0.6 μM) 高。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:9.5 nM (IC50)"},{name: "CDK2/cyclin A3:5.4 nM (IC50)"},{name: "CDK4:1.6 μM (IC50)"},{name: "DYRK1A:0.9 μM (IC50)"},{name: "PDK1:0.8 μM (IC50)"}] |
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Sayle, K.L., Bentley, J., Boyle, F.T., et al.Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2Bioorg. Med. Chem. Lett.13(18),3079-3082(2003)
Hardcastle, I.R., Arris, C.E., Bentley, J., et al.N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2J. Med. Chem.47(15),3710-3722(2004)
Pratt, D.J., Bentley, J., Jewsbury, P., et al.Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivityJ. Med. Chem.49(18),5470-5477(2006)
Krasinska, L., Cot, E., and Fisher, D.Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycleCell Cycle7(12),1702-1708(2008)
Thomas, H.D., Wang, L.Z., Roche, C., et al.Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301Eur. J. Cancer47(13),2052-2059(2011)
