PCNA-I1
Cat. No.：YN290777
| 产品名称: | PCNA-I1 |
| CAS No.: | 444930-42-1 |
| Chemical Name: | 3-methyl-2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide-2-thiophenecarboxylic acid |
| Synonyms: | |
| 分子量: | 310.4 |
| 分子式: | C17H14N2O2S |
| SMILES: | OC1=C(/C=N/NC(C2=C(C)C=CS2)=O)C=CC3=CC=CC=C31 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PCNA-I1 是一种有效的PCNA(增殖细胞核抗原)抑制剂。PCNA-I1 直接与 PCNA 三聚体结合，Kd为 0.41 μM，并在体外和体内都表现出抗肿瘤活性。 |
| IC50和靶点: | |
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Tan, Z., Wortman, M., Dillehay, K.L., et al.Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growthMol. Pharmacol.81(6),(2012)
Dillehay, K.L., Lu, S., and Dong, Z.Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate canceMol. Cancer Ther.13(12),2817-2826(2014)
