ONO-8130
Cat. No.：YN290780
| 产品名称: | ONO-8130 |
| CAS No.: | 459841-96-4 |
| Chemical Name: | 4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-benzoic acid |
| Synonyms: | |
| 分子量: | 500.6 |
| 分子式: | C25H28N2O5S2 |
| SMILES: | OC(C1=CC=C(COC2=CC(CCC3)=C3C=C2N(S(C4=NC(C)=CS4)(=O)=O)CC(C)C)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ONO-8130 是一种口服有效和选择性的前列腺素 EP1 受体 (EP1 receptor) 拮抗剂。ONO-8130 可阻断 L6 脊髓中ERK的磷酸化。ONO-8130 可减轻环磷酰胺致膀胱炎小鼠的膀胱疼痛。ONO-8130 可用于间质性膀胱炎的研究。 |
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Miki, T., Matsunami, M., Nakamura, S., et al.ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitisPain152(6),1373-1381(2011)
Säfholm, J., Dahlén, S.E., Delin, I., et al.PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptorsBr. J. Pharmacol.168(4),794-806(2013)
