Saroglitazar
Cat. No.：YN290781
CAS No. ：495399-09-2
| 产品名称: | Saroglitazar |
| CAS No.: | 495399-09-2 |
| Chemical Name: | αS-ethoxy-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]-benzenepropanoic acid |
| Synonyms: | 沙罗格列扎 |
| 分子量: | 439.5681 |
| 分子式: | C25H29NO4S |
| SMILES: | OC([C@@H](OCC)CC1=CC=C(OCCN2C(C)=CC=C2C3=CC=C(SC)C=C3)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Saroglitazar是一种新型的过氧化物酶体增殖物活化受体PPAR的激动剂，具有显著PPARα活性和中度PPARγ活性, 在HepG2细胞中的EC50值分别为0.65 pM and 3 nM。 |
| IC50和靶点: | [{name:"PPARα:0.65 pM (EC50, HepG2 cell)"},{name: "PPARγ:3 nM (EC50, HepG2 cell)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Jain, M.R., Giri, S.R., Trivedi, C., et al.Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical modelsPharmacol. Res. Perspect.3(3),e00136(2015)
Jain, M.R., Giri, S.R., Bhoi, B., et al.Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH modelsLiver Int.38(6),1084-1094(2018)
