ULS 欢迎您!
ULS 欢迎您!
> 产品中心 > 抑制剂 & 激动剂 > Epigenetics > Aurora Kinase

5,6-Dichlorobenzimidazole riboside

Cat. No.:YN290784

  • CAS No. :53-85-0

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: 5,6-Dichlorobenzimidazole riboside
      CAS No.: 53-85-0
      Chemical Name: 5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole
      Synonyms:DRB
      分子量:319.1
      分子式:C12H12Cl2N2O4
      SMILES:O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=C2C=C(Cl)C(Cl)=C3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: 5,6-Dichlorobenzimidazole riboside 是一种核苷类似物,可抑制几种羧基末端结构域激酶,包括酪蛋白激酶 II 和细胞周期依赖性激酶。5,6-Dichlorobenzimidazole riboside 在不诱导健康细胞遗传毒性应激的情况下,诱导人类结肠腺癌细胞的 p53 依赖性凋亡。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Zandomeni, R.O.Kinetics of inhibition by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole on calf thymus casein kinase IIBiochem. J.262(2),469-473(1989)

      Yankulov, K., Yamashita, K., Roy, R., et al.The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinaseJ. Biol. Chem.270(41),23922-23925(1995)

      Rickert, P., Corden, J.L., and Lees, E.Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinasesOncogene18(4),1093-1102(1999)

      Schang, L.M.Cyclin-dependent kinases as cellular targets for antiviral drugsJ. Antimicrob. Chemother.50(6),779-792(2002)

      Zandomeni, R., Zandomeni, M.C., Shugar, D., et al.Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcriptionJ. Biol. Chem.261(7),3414-3419(1986)

      Yamaguchi, Y., Wada, T., and Handa, H.Interplay between positive and negative elongation factors: drawing a new view of DRBGenes Cells3(1),9-15(1998)

      te Poele, R.H., Okorokov, A.L., and Joel, S.P.RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cellsOncogene18(42),5765-5772(1999)

      Marciniak, R.A., and Sharp, P.A.HIV-1 tat protein promotes formation of more-processive elongation complexesEMBO J.10(13),4189-4196(1991)

    • 摩尔计算器
    • 稀释计算器
    摩尔浓度计算器方程 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    计算

    质量 浓度 体积 分子量
    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
    • C1
      V1
      C2
      V2
    • 您最近查看的产品:
    相关产品


    ULS 的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)Copyright © 2020-2021 ULS. All Rights Reserved. 备案号:粤ICP备2021013238号-1
    0.320960s