PPARγ agonist 5
Cat. No.：YN290786
| 产品名称: | PPARγ agonist 5 |
| CAS No.: | 54334-04-2 |
| Chemical Name: | 5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ẟ-lactone |
| Synonyms: | |
| 分子量: | 502.59652 |
| 分子式: | C28H38O8 |
| SMILES: | O=C1[C@@]2(C)[C@@]([C@H]3C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4(O)CC[C@@]5(O)[C@@](C)(O)[C@@]6([H])CC(C)=C(C)C(O6)=O)(O3)[C@@H](O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4β-Hydroxywithanolide E 可从Physalis peruvianaL.中分离得到，可通过调节有丝分裂克隆扩增来抑制 3T3-L1 细胞的脂肪细胞分化。4β-Hydroxywithanolide E 是一种脂肪生成抑制剂，可抑制 PPARγ、C/EBPα 和脂肪细胞特异性分子 aP2 mRNA 的表达。 |
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Sang-Ngern, M., Youn, U.J., Park, E.J., et al.Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activityBioorg. Med. Chem. Lett.26(12),2755-2759(2016)
Park, E.J., Sang-Ngern, M., Chang, L.C., et al.Physalactone and 4β-hydroxywithanolide E isolated from Physalis peruviana inhibit LPS-induced expression of COX-2 and iNOS accompanied by abatement of Akt and STAT1J. Nat. Prod.82(3),492-499(2019)
Ye, Z.N., Yuan, F., Liu, J.Q., et al.Physalis peruviana-derived 4β-hydroxywithanolide E, a novel antagonist of Wnt signaling, inhibits colorectal cancer in vitro and in vivoMolecules24(6),E1146(2019)
