Macbecin I
Cat. No.：YN290806
| 产品名称: | Macbecin I |
| CAS No.: | 73341-72-7 |
| Chemical Name: | 6,17-didemethoxy-15R-methoxy-6-methyl-11-O-methyl-geldanamycin |
| Synonyms: | Macbecin I; NSC 330499 |
| 分子量: | 558.7 |
| 分子式: | C30H42N2O8 |
| SMILES: | CO[C@@]([H])(C(C(C(NC(/C(C)=C/C=C/[C@@H]([C@H](/C(C)=C/1)OC(N)=O)C)=O)=C2)=O)=CC2=O)[C@@H](C)C[C@H](OC)[C@@H](OC)[C@H]1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Macbecin 是一种稳定的HSP90抑制剂，与 ATP 结合位点结合，IC50为 2 μM，Kd为 0.24 μM。Macbecin 具有抗肿瘤活性和细胞毒性。 |
| IC50和靶点: | [{name:"HSP90:2 μM (IC50)"},{name: "HSP90:0.24 μM (Kd)"}] |
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| Solvent & Solubility: |
Martin, C.J., Gassier, S., Challis, I.R., et al.Molecular characterization of macbecin as an Hsp90 inhibitorJ. Med. Chem.51(9),2853-2857(2008)
