(E/Z)-BIO-acetoxime
Cat. No.：YN290807
| 产品名称: | (E/Z)-BIO-acetoxime |
| CAS No.: | 740841-15-0 |
| Chemical Name: | 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one |
| Synonyms: | GSK-3 Inhibitor X |
| 分子量: | 398.2 |
| 分子式: | C18H12BrN3O3 |
| SMILES: | CC(O/N=C(/C(N1)=C2C(NC3=C\2C=CC(Br)=C3)=O)C4=C1C=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) 是一种有效的选择性 GSK-3α/β 抑制剂，IC50为 10 nM。(E/Z)-BIO-acetoxime 对GSK-3α/β具有超过CDK5/p25，CDK2/cyclin A和CDK1/cyclin B(IC50=2.4, 4.3, 63 μM) 200 倍的选择性。 |
| IC50和靶点: | [{name:"GSK-3α:10 nM (IC50)"},{name: "GSK-3β:10 nM (IC50)"},{name: "Cdk5/p25:2.4 μM (IC50)"},{name: "CDK2/cyclinA:4.3 μM (IC50)"},{name: "CDK1/cyclinB:63 μM (IC50)"}] |
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Meijer, L., Skaltsounis, A.L., Magiatis, P., et al.GSK-3-selective inhibitors derived from tyrian purple indirubinsChem. Biol.10(12),1255-1266(2003)
Polychronopoulos, P., Magiatis, P., Skaltsounis, A.L., et al.Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinasesJ. Med. Chem.47(4),935-946(2004)
Wang, B., Liu, J., Ma, L.N., et al.Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44+ gastric cancer cells via attenuating Wnt signalingJ. Gastroenterol.48,798-808(2013)
Hsu, M.J., and Hung, S.L.Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cellsArch. Virol.158(6),1287-1296(2013)
